Comparative genomics using myosin heavy chain gene of 3 related Essay

Comparative genomics using myosin heavy chain gene of 3 related species human,rat,rabbit and 3 unrelated human,fish,chicken just 3000 word introduction only - Essay Example The encoding of genes that isoforms Myosin Heavy Chains have been developed according to their transcriptional orientations and linear order within the set kb of 350 in human, rat, and rabbit. From the maps it is noted that transcriptional orientation, relative intragenic distances, and order of the genes are conserved between the species. Unlike other gene families that are clustered, the order does not portray the temporal patterns of those genes. Conversely, the gene organization, conservation from the divergence of the genes shows that the organization of the genes can be important for their function and regulation. Myosin Heavy Chains converts chemical energy from the hydrolysis of ATP to form a mechanical force that moves the motile processes like cytokines, cellular locomotion, and vesicular transport in eukaryotic cells. Myosin Heavy Chains are subdivided into class comprising of 9 to 11 classes. The conventional Myosin Heavy Chains include the sarcomere Myosin Heavy Chains that associates itself to form a function enzymatically and filaments in promoting contraction in striated muscles. Muscle myosin consists of double Myosin Heavy Chains and two associated dissimilar myosin light chains pairs. The seven Myosin Heavy Chains isoforms that dominate the mammalian skeletal muscles are 2 developmental isoforms, Myosin Heavy Chains embryonic and Myosin Heavy Chains perinatal; 3 adult skeletal muscles, Myosin Heavy Chains-Ha, Myosin Heavy Chains-IIb, Myosin Heavy Chains-IIx/d, and Myosin Heavy Chains-ß/slow which is outlined in the cardiac muscles. The Myosin Heavy Chains isoforms are regulate d differently in response to diverting stimuli that include mechanical, physiological, hormonal, and other signals. The activity of ATPase conferred by the Myosin Heavy Chains in a muscle correlated the contraction speed, thus Myosin Heavy Chains are the